Liposomal and Lipid Nanoparticle Drug Delivery Systems Stimulated by COVID-19

Nanoparticle drug delivery systems are engineering technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Modern forms of  drug delivery systems should minimize side effects and reduce both dosing and dosing frequency. Recently, nanoparticles have attracted attention due to their promising application in effective drug delivery.

Liposomes offer a unique opportunity to deliver drug molecules into cells or intracellular compartments as they protect loaded drug molecules from external degradation and resemble biological membranes… Physicochemical properties (size, charge,  surface functional ligands, etc.)—can be altered, resulting in advantageous features for specific drug delivery tasks. These advantages have made liposomes a leading drug delivery platform with  wide clinical applications.

Lipid nanoparticle drugs are liposome-like structures specifically designed to encapsulate a  variety of nucleic acids (RNA and DNA). As such, they are the most popular non-viral gene delivery systems. Exelead develops and manufactures LNPs that encapsulate different types of gene payloads, including siRNA, mRNA and saRNA.

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